Reaction Sequences


Biocatalytic cascades and one-pot multi-step enzymatic reactions have attracted growing interest owing to several important advantages:

  • Alternative cofactor regeneration systems for redox enzymes e.g., ‘smart cosubstrates’ and biocatalytic cascades.
  • Higher product yields and productivities achieved by such designs.
  • Chemo-, regio-, and stereoselectivity of various biocatalysts.

 

Nowadays, redox enzymes that usually require expensive cofactors for the electron transfer between molecules are mostly coupled in a cascade fashion. This allows simultaneous cofactor regeneration enabling more efficient and economical oxidation as well as reduction.

Group Leader: Dr. Selin Kara


Research Fields

    • Alternative cofactor regeneration systems for redox enzymes e.g., ‘smart cosubstrates’ and biocatalytic cascades.
    • Multi-enzymatic and chemo-enzymatic cascades for chemical transformations.
    • Process optimisation using Design of Experiments (DoEs).
    • Stabilisation of enzymes by means of immobilisation and additives.