Publications Dr. Selin Kara

Dr. Selin Kara was the former group leader of the ITB group ‘Reaction Sequences’.

Journal Articles


  • M. Aßmann, S. Gaßmeyer, C. Mügge, J. Enoki, L. Hilterhaus, R. Kourist, A. Liese*, S. Kara*, Improvement of the process stability of arylmalonate decarboxylase by immobilization for biocatalytic profen synthesis, Frontiers in Microbiology,
  •  C. Scherkus, S. Schmidt, U.T. Bornscheuer, H. Gröger, S. Kara, A. Liese*, Kinetic insights into e-caprolactone synthesis: improvement of an enzymatic cascade reaction, Biotechnology and Bioengineering, DOI: 10.1002/bit.26258
  • L. Pesci, S. Glueck, K. Faber, A. Liese*, S. Kara*, Route to the fragrance compound 4-ethylguaiacol via a two-step chemo-enzymatic reaction sequence, Organic Process Research & Development 2017, 21, 85–93
  • M. Rauch, S. Schmidt, I.W.C.E. Arends, K. Oppelt, S. Kara, F. Hollmann*, Photocatalytic alcohol oxidation using LED light sources, Green Chemistry 2017, 19, 376–379            


  • C. Scherkus, S. Schmidt, U.T. Bornscheuer, H. Gröger, S. Kara, A. Liese*, A fed-batch synthetic strategy for a multi-enzymatic synthesis of poly-ε-caprolactone, ChemCatChem 2016, 8, 3446–3452
  • L. Pesci, S. Kara, A. Liese*, Evaluation of the substrate scope of benzoic acid (de)carboxylases according to chemical and biochemical parameters, ChemBioChem 2016, 17, 1845–1850
  • A. Bornadel, R. Hatti-Kaul, F. Hollmann, S. Kara*, Enhancing the productivity of the bi-enzymatic convergent cascade for e-caprolactone synthesis through design of experiments and a biphasic system, Tetrahedron 2016, 72, 7222–7228


  • A. Bornadel, R. Hatti-Kaul, F. Hollmann, S. Kara*, A bi-enzymatic convergent cascade for e-caprolactone synthesis employing 1,6-hexanediol as a ‘double-smart cosubstrate’, ChemCatChem 2015, 7, 2442–2445
  • S. Kara*, J.H. Schrittwieser, S. Gargiulo, Y. Ni, H. Yanase, D.J. Opperman, W.J.H. van Berkel, I.W.C.E. Arends, F. Hollmann*, Complete enzymatic oxidation of methanol to carbon dioxide: Towards more eco-efficient regeneration systems for reduced nicotinamide cofactors, Advanced Synthesis & Catalysis 2015, 357, 1687–1691, VIP Paper
  • R. Zuhse, C. Leggewie, F. Hollmann, S. Kara*, Scaling-up of ‘smart cosubstrate’ 1,4-butanediol promoted asymmetric reduction of ethyl-4,4,4-trifluoroacetoacetate in organic media, Organic Process Research & Development 2015, 19, 369–372
  • M. Berheide, S. Kara*, A. Liese*, Reversibility of asymmetric catalyzed C–C Bond formation by benzoylformate decarboxylase, Catalysis Science & Technology 2015, 5, 2418–2426, Hot Article
  • A. Petrenz, P. Domínguez de María, A. Ramanathan, U. Hanefeld, M.B. Ansorge-Schumacher*, S. Kara*, Medium and reaction engineering for the establishment of a chemo-enzymatic dynamic kinetic resolution of rac-benzoin in batch and continuous mode, Journal of Molecular Catalysis B: Enzymatic 2015, 14, 42–49


  • S. Kochius, Y. Ni, S. Kara, S. Gargiulo, J. Schrader, D. Holtmann, F. Hollmann*, Light-accelerated biocatalytic oxidation reactions, ChemPlusChem 2014, 79, 1554–1557
  • S. Kara*, D. Spickermann, A. Weckbecker, C. Leggewie, I.W.C.E. Arends, F. Hollmann*, Bioreductions catalyzed by an alcohol dehydrogenase in non-aqueous media, ChemCatChem 2014, 6, 973–976
  • S. Bisagni*, B. Summers, S. Kara, R. Hatti-Kaul, G. Grogan, G. Mamo, F. Hollmann, Exploring the substrate specificity and enantioselectivity of a Baeyer-Villiger monooxygenase from Dietzia sp. D5: oxidation of sulfides and aldehydes, Topics in Catalysis 2014, 57, 366–375
  • D. Spickermann, S. Kara, I. Barackov, F. Hollmann, U. Schwaneberg, P. Dünkelmann, C. Leggewie*, Enzyme stabilization by additives under industrial relevant reaction conditions, Journal of Molecular Catalysis B: Enzymatic 2014, 103, 24–28


  • S. Kara, D. Spickermann, J.H. Schrittwieser, A. Weckbecker, C. Leggewie, I.W.C.E. Arends, F. Hollmann*, Access to achiral/chiral lactones by Horse Liver Alcohol Dehydrogenase-catalyzed oxidation in two-liquid phase systems, ACS Catalysis 2013, 3, 2436–2439
  • J.H. Schrittwieser*, F. Coccia, S. Kara, B. Grischek, W. Kroutil, N. d’Alessandro, F. Hollmann*, One-pot combination of enzyme and Pd nanoparticle catalysis for the synthesis of enantiomerically pure 1,2-amino alcohols, Green Chemistry 2013, 15, 3318–3331, Hot Paper
  • S. Kara, D. Spickermann, J.H. Schrittwieser, C. Leggewie, W.J.H. van Berkel, I.W.C.E. Arends, F. Hollmann*, More efficient redox biocatalysis by utilising 1,4-butanediol as a ‘smart cosubstrate’, Green Chemistry 2013, 15, 330–335, Hot Paper
  • Könst, S. Kara, S. Kochius, D. Holtmann, I.W.C.E. Arends, R. Ludwig, Hollmann*, Expanding the scope of laccase-mediator systems ChemCatChem 2013, 5, 3027–3032


  • P. Könst, H. Merkens, S. Kara, S. Kochius, A. Vogel, R. Zuhse, D. Holtmann, I.W.C.E Arends, F. Hollmann*, Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase, Angewandte Chemie (Int. Ed.) 2012, 51, 9914–9917


  • S. Kara, W.S. Long, M. Berheide, S. Peper, B. Niemeyer, A. Liese*, Influence of reaction conditions on the enantioselectivity of biocatalyzed CC bond formations under high pressure conditions, Journal of Biotechnology 2011, 152, 87–92
  • S. Peper, S. Kara, W.S. Long, A. Liese, B. Niemeyer*, Immobilization and characterization of benzoylformate decarboxylase from Pseudomonas putida on spherical silica, Bioprocess and Biosystems Engineering 2011, 34, 671–680


Book Chapters


  • S. Kara, J.H. Schrittwieser and F. Hollmann*, Strategies for cofactor regeneration in biocatalyzed reductions, In: Synthetic Methods for Biologically Active Molecules: Exploiting the Potential of Bioreductions (Brenna, E. eds.), pp. 209–238, Wiley-Blackwell, 2013 Print ISBN: 9783527333875, Online ISBN: 9783527665785, DOI: 10.1002/9783527665785.ch08


  • S. Kara and A. Liese*, Enzymatic CC bond formation, asymmetric, In: Encyclopedia of Industrial Biotechnology. Bioprocess, Bioseparation, and Cell Technology (Flickinger, M.C. eds.), 3, pp. 2034–2049, Wiley-VCH, 2010 , ISBN-10: 0-471-79930-0, ISBN-13: 978-0-471-79930-6



  • F. Hollmann* and S. Kara, Biokatalyse in unkonventionellen Reaktionsmedien, BIOspektrum 2014, 01, 100–102
  • S. Kara*, J.H. Schrittwieser, F. Hollmann, M.B. Ansorge-Schumacher*, Recent trends and novel concepts in cofactor-dependent biotransformations, Applied Microbiology and Biotechnology 2014, 98, 1517–1529


  • S. Kara, J.J. Mueller, A. Liese*, Online analysis methods for monitoring of bioprocesses, Chimicaoggi-Chemistry TODAY 2011, 29, 38–41

Conference Papers


  • A. Petrenz, A. Ramanathan, P. Domínguez de María, U. Hanefeld, S. Kara, M.B., Ansorge-Schumacher* , Chemo-enzymatische heterogenkatalysierte Eintopfsynthese von enantiomerenreinem Benzoin, Chemie Ingenieur Technik 2014, 86(9), 1488


  • S. Kara*, Fluoreszenzspektroskopie als neue Methode für die Online-Analyse biokatalytischer C–C-Knüpfungsreaktionen, Chemie Ingenieur Technik 2009, 82(9), 1528–1529