Publications Prof. Andreas Liese


          • A. Malvis Romero, J. J. Picado Morales, L. Klose, A. Liese
            Enzyme-Assisted Extraction of Ulvan from the Green Macroalgae Ulva fenestrata
            Molecules (2023)
            DOI: 10.3390/molecules28196781
          • G. V. Sayoga, V. S. Bueschler, H. Beisch, D. Holtmann, A. P. Zeng, B. Fiedler, D. Ohde, A. Liese
            Application of the all-in-one electrode for in situ H2O2 generation in hydroxylation catalyzed by unspecific peroxygenase from Agrocybe aegerita
            Molecular Catalysis (2023)
            DOI: 10.1016/j.mcat.2023.113325
          • L. Klose, N. Meyer-Heydecke, S. Wongwattanarat, J. Chow, P. Pérez García, C. Carré, W. Streit, G. Antranikian, A. Malvis Romero, A. Liese
            Towards Sustainable Recycling of Epoxy-Based Polymers: Approaches and Challenges of Epoxy Biodegradation
            Polymers (2023)
            DOI: 10.3390/polym15122653
          • A. Malvis Romero, F. Brozio, S. Kammler, C. Burkhardt, L. Baruth, M. Kaltschmitt,
            G. Antranikian, A. Liese
            Enzyme-assisted extraction of alginate from beach wrackfucus vesiculosus
            Chemie Ingenieur Technik (2023)
            DOI: 10.1002/cite.202200173


          • B. Thomas, D. Ohde, S. Matthes, P. Bubenheim, K. Terasaka, M. Schlüter, A. Liese
            Enhanced enzyme stability and gas utilization by microbubble aeration applying microporous aerators
            Catalysis Science & Technology (2022)
            DOI: 10.1039/D2CY01761J
          • L. Geuer, G. Liese, A. Liese, S. Perret, A. Schlindwein, R. Ulber
            „Experimente aus der Kiste“ – Kultivierung von Mikroorganismen; Biotechnologische Ansätze mit Alltagsbezug für den forschungsorientierten MINT-Unterricht
            Chemie in unserer Zeit
          • A. E. Ünlü, B. Prasad, K. Anavekar, P. Bubenheim, A. Liese
            The effect of natural deep eutectic solvents on laccase activity and oligomerization of rutin
            Taylor & Francis, Biocatalysis and Biotransformation (2022) online
            DOI: 10.1080/10242422.2022.2120391
          • J.-O. Kundoch, T. Hassemer, D. Ohde, A. Liese
            Novel technique for monitoring thermal unfolding of enzymes in crude mixtures
            Chemie Ingenieur Technik 94 (9) (2022) 1276-1277
            DOI: 10.1002/cite.202255197
          • J. A. Reich, M. Aßmann, K. Hölting, P. Bubenheim, J. Kuballa, A. Liese
            Shift of reaction equilibrium at high pressure in the continuous synthesis of neuraminic acid
            Beilstein Journal of Organic Chemistry 18 (2022) 567-579
            DOI: 10.3762/bjoc.18.59
          • N. Widderich, N. Mayer, A. J. Ruff, B. Reckels, F. Lohkamp, C. Visscher, U. Schwaneberg, M. Kaltschmitt, A. Liese, P. Bubenheim
            Conditioning of feed material prior to feeding: Approaches for a sustainable phosphorus utilization
            Sustainability 14 (2022) 3998
            DOI: 10.3390/su14073998
          • B. O. Burek, A. W. H. Dawood, F. Hollmann, A. Liese, D. Holtmann
            Process intensification as game changer in enzyme catalysis
            Frontiers in Catalysis 2 (2022) Online, 21 March 2022
            DOI: 10.3389/fctls.2022.858706
          • D. Eixenberger, A.-F. Carballo-Arce, J.-R. Vega-Baudrit, H. Trimino-Vazquez , L. R. Villegas-Penaranda , A. Stöbener, F. Aguilar, J.-A. Mora-Villalobos, M. Sandoval-Barrantes, P. Bubenheim, A. Liese
            Tropical agroindustrial biowaste revalorization through integrative biorefineries – review part II: pineapple, sugarcane and banana by-products in Costa Rica
            Biomass conversion and biorefinery (2022) Online, 08 May 2022
            DOI: 10.1007/s13399-022-02721-9


          • J.-A. Mora-Villalobos, F. Aguilar, A. Francis Carballo-Arce, J.-R. Vega-Baudrit, H. Trimino-Vazquez, L. Villegas-Penaranda, A. Stöbener, D. Eixenberger, P. Bubenheim, M. Sandoval, A. Liese
            Tropical agroindustrial biowaste revalorization through integrative biorefineries—review part I: coffee and palm oil by-products
            Biomass Conversion and Biorefinery (2021) ACCEPTED
          • G. Liese, J. Husung
            Mit Hefe und Netiquette
            Digital unterrichten BIOLOGIE 10 (2021) 4-5
          • C. Plass, N. Adebar, R. Hiessl, J. Kleber, A. Grimm, A. Langsch, R. Otter, A. Liese, H. Gröger
            Structure-performance guided design of sustainable plasticizers from bio-renewable feedstocks
            European Journal of Organic Chemistry (2021) Online
            DOI: 10.1002/ejoc.202101014
          • F. Meyer, J. Johannsen, A. Liese, G. Fieg, P. Bubenheim, T. Waluga
            Evaluation of process integration for the intensification of a biotechnological process
            Chemical Engineering and Processing: Process Intensification 167 (2021) 108506
          • J. Johannsen, F. Meyer, C. Engelmann, A. Liese, G. Fieg, P. Bubenheim, T. Waluga
            Multi‐enzyme cascade reaction in a miniplant two‐phase‐system : Model validation and mathematical optimization
            AIChE Journal 67 (4) (2021) 1-10
            DOI: 10.1002/aic.17158
          • D. Ohde, B. Thomas, S. Matthes, S. Tanaka, P. Bubenheim, K. Terasaka, M. Schlüter, A. Liese
            Microbubble enhanced mass transfer efficiency of CO2 capture utilizing aqueous triethanolamine for enzymatic resorcinol carboxylation
            RSC Advances 11 (7) (2021) 4087-4096
            DOI: 10.1039/D0RA08690H
          • B. Thomas, D. Ohde, S. Matthes, C. Engelmann, P. Bubenheim, K. Terasaka, M. Schlüter, A. Liese
            Comparative investigation of fine bubble and macrobubble aeration on gas utility and biotransformation productivity
            Biotechnology & Bioengineering 118 (1) (2021) 130-141
            DOI: 10.1002/bit.27556
          • D. Ohde, B. Thomas, P. Bubenheim, A. Liese
            Enhanced CO2 fixation in the biocatalytic carboxylation of resorcinol: Utilization of amines for amine scrubbing and in situ product precipitation
            Biochemical Engineering Journal 166 (2021) 107825
            DOI: 10.1016/j.bej.2020.107825


          • S. Matthes, B. Thomas, D. Ohde, M. Hoffmann, P. Bubenheim, A. Liese, S. Tanaka, K. Terasaka, M. Schlueter
            Hydrodynamic and mass transfer correlation in a microbubble aerated stirred tank reactor
            Journal of Chemical Engineering of Japan 53 (10) (2020) 577-584
            DOI: 10.1252/jcej.19we181
          • C. Engelmann, J. Johannsen, T. Waluga, G. Fieg, A. Liese, P. Bubenheim
            A multi-enzyme cascade for the production of high value aromatic compounds
            Catalysts 10 (10) (2020) 1216
            DOI: 10.3390/catal10101216
          • Perz, S. Bormann, H-G. Hennemann, F. Nissen, F. Hollmann, D. Holtmann, P. Bubenheim, A. Liese
            Biocatalytic oxyfunctionalization of butane in a bubble‐column reactor
            Chemie Ingenieur Technik 92 (9) (2020) 1211
            DOI: 10.1002/cite.202055313
          • B. Thomas, D. Ohde, S. Matthes, C. Engelmann, P. Bubenheim, K. Terasaka, M. Schlüter, A. Liese
            Comparative investigation of fine bubble and macrobubble aeration on gas utility and biotransformation productivity
            Biotechnology & Bioengineering (2020) ACCEPTED
            DOI: 10.1002/bit.27556
          • D. Ohde, B. Thomas, P. Bubenheim, A. Liese
            Enhanced CO2 fixation in the biocatalytic carboxylation of resorcinol: Utilization of amines for amine scrubbing and ISPR
            Biochemical Engineering Journal (2020) ACCEPTED
          • G. Liese, J. Husung, I. Klose, J. Lehmann, A. Liese
            Digitale und analoge MINT-Bildungskonzepte, die Schule, Hochschule und Unternehmen zusammenbringen
            Chemie Ingenieur Technik 92 (9) (2020) 1185
            DOI: 10.1002/cite.202055136
          • K. Schlipköter, T. Betke, J. Kleber, H. Gröger, A. Liese
            Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation
            Organic & Biomolecular Chemistry 18 (39) (2020) 7862-7867
            DOI: 10.1039/d0ob01561J
          • C. Plass, R. Hiessl, J. Kleber, A. Grimm, A. Langsch, R. Otter, A. Liese, H. Gröger
            Towards bio-based plasticizers with reduced toxicity: Synthesis and performance testing of a 3-methylphthalate
            Sustainable Chemistry and Pharmacy 18 (2020) 100319
            DOI: 10.1016/j.scp.2020.100319
          • R. Hiessl, L. Hennecke, C. Plass, J. Kleber, S. Wahlefeld, R. Otter, H. Gröger, A. Liese
            FTIR based kinetic characterisation of an acid-catalysed esterification of 3-methylphthalic anhydride and 2-ethylhexanol
            Analytical Methods 12 (24) (2020) 3137-3144
            DOI: 10.1039/d0ay00686f
          • S. Lütz, A. Liese
            30 Jahre sichere Gentechnik in Deutschland
            30 years of safe genetic engineering in Germany

            Angewandte Chemie 132 (33) (2020) 13772-13773
            Angewandte Chemie Int. Ed. 59 (33) (2020) 13668-13669
            DOI: 10.1002/ange.202006430
            DOI: 10.1002/anie.202006430
          • N. Büscher, C. Spille, J. K. Kracht, G. V. Sayoga, A. W. H. Dawood, M. I. Maiwald, D. Herzog, M. Schlüter, A. Liese
            Countercurrently operated reactive extractor with an additively manufactured enzyme carrier structure
            Organic Process Research & Development (2020)
            DOI: 10.1021/acs.oprd.0c00205
          • F. Perz, S. Bormann, R. Ulber, M. Alcalde, P. Bubenheim, F. Hollmann, D. Holtmann, A. Liese
            Enzymatic oxidation of butane to 2-butanol in a bubble column
            ChemCatChem 12 (2020) 3666-3669
            DOI: 10.1002/cctc.202000431
          • Johannsen, C. Engelmann, A. Liese, G. Fieg, P. Bubenheim, T. Waluga
            Pilot-scale operation of a multi-enzymatic cascade reaction in a multiphase system
            Chemical Engineering Transactions 79 (2020) 25-30
            DOI: 10.3303/CET2079005
          • N. Noirungsee, S. Hackbusch, J. Viamonte, P. Bubenheim, A. Liese, R. Müller
            Influence of oil, dispersant and pressure on microbial communities from the Gulf of Mexico
            Scientific Reports (2020) 10:7079
            DOI: 10.1038/s41598-020-63190-6
          • C. Engelmann, N. Ekambaram, J. Johannsen, O. Fellechner, T. Waluga, G. Fieg, A. Liese, P. Bubenheim
            Enzyme immobilization on synthesized nanoporous silica particles and their application in a bi-enzymatic reaction
            ChemCatChem (2020)
            DOI: 10.1002/cctc.201902293 (ACCEPTED/Online open AID – 16674649)
          • G. Sluyter, J. Kleber, F. Perz, B. Grund, S. Leuchs, S. Sieberz, P. Bubenheim, O. Thum, A. Liese
            Fermentative Oxidation of Butane in Bubble Column Reactors
            Biochemical Engineering Journal (2020)
            DOI: 10.1016/j.bej.2020.107486


          • D. Ohde, B. Thomas, S. Matthes, Z. Percin, C. Engelmann, P. Bubenheim, K. Terasaka, M. Schlüter, A. Liese
            Fine Bubble‐based CO 2 Capture Mediated by Triethanolamine Coupled to Whole Cell Biotransformation
            Chemie Ingenieur Technik 91 (2019) 1822-1826
            DOI: 10.1002/cite.201900113
          • A. Stöbener, M. Fabuel Ortega, C. J. Bolten, E. Ananta, S. Nalur, A. Liese
            In situ Monitoring of the Biocatalyzed Partial Hydrolysis of Cocoa Butter and Palm Oil Fraction
            International Journal of Food Science and Technology 6 (2019) 32422
            DOI: 10.1111/ijfs.14366
          • S. Hackbusch, N. Noirungsee, J. Viamonte Dominguez, X. Sun, P. Bubenheim, J. Kostka, R. Mueller, A. Liese
            Influence of pressure and dispersant on oil biodegradation by a newly isolated Rhodococcus strain from deep-sea sediments of the Gulf of Mexico
            Marine Pollution Bulletin (2019) 110683
            DOI: 10.1016/j.marpolbul.2019.110683
          • M. Pätzold, S. Siebenhaller, S. Kara, A. Liese, C. Syldatk, D. Holtmann
            Deep eutectic solvents as efficient solvents in biocatalysis
            Trends in Biotechnology 37 (2019) 943-959
            DOI: 10.1016/j.tibtech.2019.03.007
          • N. Büscher, G. Sayoga, K. Rübsam, F. Jakob, U. Schwaneberg, S. Kara, A. Liese
            Biocatalyst immobilization by anchor peptides on an additively manufacturable material
            Organic Process Research & Development 23 (2019) 1852-1859
            DOI: 10.1021/acs.oprd.9b00152
          • A. Stöbener, U. Naefken, J. Kleber, A. Liese
            Determination of trace amounts with ATR FTIR spectroscopy and chemometrics: 5-(hydroxymethyl)furfural in honey
            Talanta 204 (2019) 1-5
            DOI: 10.1016/j.talanta.2019.05.092
          • M. Pätzold, B. O. Burek, A. Liese, J. Z. Bloh, D. Holtmann
            Product recovery of an enzymatically synthesized (-)-menthol ester in a deep eutectic solvent
            Bioprocess and Biosystems Engineering 42 (2019) 1385-1389
            DOI: 10.1007/s00449-019-02125-6
          • M. Pätzold, A. Weimer, A. Liese, D. Holtmann
            Optimization of solvent-free enzymatic esterification in eutectic substrate reaction mixture
            Biotechnology Reports 24 (2019) e00333
            DOI: 10.1016/j.btre.2019.e00333


          • Hümmer, S. Kara, A. Liese, I. Huth, J. Schrader, D. Holtmann
            Synthesis of (-)-menthol fatty acid esters in and from (-)-menthol and fatty acids – novel concept for lipase catalyzed esterification based on eutectic solvents
            Molecular Catalysis 458 (2018) 67-72
            DOI: 10.1016/j.mcat.2018.08.003
          • S. Molla, A. Himmelspach, R. Wohlgemuth, E. T.K. Haupt, A. Liese
            Mechanistic and kinetics elucidation of Mg2+/ATP molar ratio effect on glycerol kinase
            Molecular Catalysis 445 (2018) 36-42
            DOI: 10.1016/j.mcat.2017.11.006


          • Pesci, P. Gurikov, A. Liese, S. Kara
            Amine-mediated enzymatic carboxylation of phenols using CO2 as substrate increases equilibrium conversions and reaction rates
            Biotechnology Journal 12 (2017) 1-7
            DOI: 10.1002/biot.201700332
          • Gebhard, B. Neuer, G.A. Luinstra, A. Liese
            Enzyme- and metal-catalyzed synthesis of a new biobased polyester
            Organic Process Research & Development 21 (9) (2017) 1245-1252
            DOI: 10.1021/acs.oprd.6b00418
          • Ezgi Ünlü, B. Prasad, K. Anavekar, P. Bubenheim, A. Liese
            Investigation of a green process for the polymerization of catechin
            Preparative biochemistry & biotechnology 47 (9) (2017) 918-924
            DOI: 10.1080/10826068.2017.1365241
          • Aßmann, A. Stöbener, C. Mügge, S. K. Gaßmeyer, L. Hilterhaus, R. Kourist, A. Liese, S. Kara
            Reaction engineering of biocatalytic (S)-naproxen synthesis integrating in-line process monitoring by Raman spectroscopy
            Reaction Chemistry & Engineering 33 (5) (2017) 302
            DOI: 10.1039/c7re00043j
          • S. Kuhn, G. Sluyter, M.-A. Christlieb, R. Heils, A. Stöbener, J. Kleber, I. Smirnova, A. Liese
            In Situ Separation of the Chiral Target Compound (S)-2-Pentanol in Biocatalytic Reactive Distillation
            Industrial & Engineering Chemistry Research 56 (22) (2017) 6451–6461
            DOI: 10.1021/acs.iecr.7b01163
          • L. Pesci, M. Baydar, S. Glueck, K. Faber, A. Liese, S*/*. Kara
            Development and scaling-up of the fragrance compound 4-Ethylguaiacol synthesis via a two-step chemo-enzymatic reaction sequence
            Organic Process Research & Development 21 (1) (2017) 85-93
            DOI: 10.1021/acs.oprd.6b00362
          • F. Uthoff, A. Reimer, A. Liese, H. Gröger
            Enzymatic resolution of an amine under solvent-free conditions with diethyl malonate as reagent for acylation
            Sustainable Chemistry and Pharmacy 5 (2017) 42-45
            DOI: 10.1016/j.scp.2016.12.002
          • S. Wedde, P. Rommelmann, C. Scherkus, S. Schmidt, U. T. Bornscheuer, A. Liese, H. Gröger
            An alternative approach towards poly-ε-caprolactone through a chemoenzymatic synthesis: combined hydrogenation, bio-oxidations and polymerization without the isolation of intermediates
            Green Chemistry 19 (2017) 1286-1290
            DOI: 10.1039/c6gc02529c
          • G. S. Molla, B. M. Kinfu, J. Chow, W. Streit, R. Wohlgemuth, A. Liese
            Bioreaction engineering leading to efficient synthesis of L-glyceraldehyde-3-phosphate
            Biotechnology Journal 12 (3) (2017)
            DOI: 10.1002/biot.201600625
          • D. Sellin, R. Hiessl, M. Bothe, J. Timmermann, M. Becker, M. Schlüter, A. Liese
            Simultaneous local determination of mass transfer and residence time distributions in organic multiphase systems
            Chemical Engineering Journal 321 (2017) 635-641
            DOI: 10.1016/j.cej.2017.03.150
          • C. Scherkus, S. Schmidt, U. T. Bornscheuer, H. Gröger, S. Kara, A. Liese
            Kinetic insights into ε-caprolactone synthesis: improvement of an enzymatic cascade reaction
            Biotechnology and Bioengineering 114 (6) (2017) 1215-1221
            DOI: 10.1002/bit.26258
          • M. Aßmann, C. Mügge, S. K. Gaßmeyer, J. Enoki, L. Hilterhaus, R. Kourist, A. Liese, S. Kara
            Improvement of the process stability of arylmalonate decarboxylase by immobilization for biocatalytic profen synthesis
            Frontiers in Microbiology 8 (2017) 448
            DOI: 10.3389/fmicb.2017.00448
          • R. Wohlgemuth, A. Liese, W. Streit
            Biocatalytic Phosphorylations of Metabolites: Past, Present and Future
            Trends in Biotechnology 35 (5) (2017) 452-465
            DOI: 10.1016/j.tibtech.2017.01.005


          • K. Gaßmeyer, J. Wetzig, C. Mügge, M. Assmann, J. Enoki, L. Hilterhaus, R. Zuhse,
            K. Miyamoto, A. Liese, R. Kourist
            Arylmalonate decarboxylase-catalyzed asymmetric synthesis of both enantiomers of optically pure flurbiprofen
            ChemCatChem 8 (5) (2016) 916-921
            DOI: 10.1002/cctc.201501205
          • S. Molla, R. Wohlgemuth, A. Liese
            One-pot enzymatic reaction sequence for the syntheses of D-glyceraldehyde 3-phosphate and l-glycerol 3-phosphate
            Journal of Molecular Catalysis B: Enzymatic, 124 (2016) 77-82
            DOI: 10.1016/j.molcatb.2015.12.004
          • S. Molla, P. J. Venkatesh, A. Liese
            Single-pot enzymatic reaction sequence for the synthesis of D -glyceraldehyde-3-phosphate
            Chemie Ingenieur Technik, 86 (9) (2014), 1424
            DOI: 10.1002/cite.201450599
          • Baum, E. Ritter, I. Smirnova, M. Schilling, A. Liese
            The role of phase behavior in the enzyme catalyzed synthesis of glycerol monolaurate
            RSC Advances 6 (38) (2016) 32422-32429
            DOI: 10.1030/c6ra05181b
          • N. Mitrev, A. Y. Mehandzhiyski, D. I. Batovska, A. Liese, B. Galunsky
            Original enzyme-catalyzed synthesis of chalcones: utilization of hydrolase promiscuity
            Journal of the Serbian Chemical Society, 81 (11) (2016) 1231-1237
            DOI: 10.2298/JSC160422069M
          • Weiland-Bräuer, M. J. Kisch, N. Pinnow, A. Liese, R. A. Schmitz
            Highly effective inhibition of biofilm formation by the first metagenome-derived AI-2 quenching enzyme
            Frontiers in Microbiology 7 (2016) article 1098
            DOI: 10.3389/fmicb.2016.01098
          • Pesci, S. Kara, A. Liese
            Evaluation of the substrate scope of benzoic acid (de)carboxylases according to chemical and biochemical parameters
            ChemBioChem 17 (19) (2016) 1845-1850
            DOI: 10.1002/cbic.201600333
          • Heils, X. Hu, A. Liese, I. Smirnova
            In situ production and renewal of biocatalytic coatings for use in enzymatic reactive distillation
            Chemical Engineering Journal 306 (2016) 992-1000
            DOI: 10.1016/j.cej.2016.08.031
          • Brummund, M. Müller, T. Schmitges, I. Kaluzna, D. Mink, L. Hilterhaus, A. Liese
            Process development for oxidations of hydrophobic compounds applying cytochrome P450 monooxygenases in-vitro
            Journal of Biotechnology 233 (2016) 143-150
            DOI: 10.1016/j.jbiotec.2016.07.002
          • Elleuche, P. Esselun, R. Grote, B. Klippel, A. Krüger, A. Liese, M. Ostrop, C. Schäfers, C. Schröder, G. Antranikian
            8th International Congress on Biocatalysis (biocat2016), Hamburg, Germany, 28th August – 1st September, 2016
            Catalysts 6 (10) (2016) 160
            DOI: 10.3390/catal6100160